Disseminated Langerhans Cell Histiocytosis Presenting as Cholestatic Jaundice
Published: February 1, 2015 | DOI: https://doi.org/10.7860/JCDR/2015/.5550
Rohit Kapoor, Anthony M. Loizides, Soumya Sachdeva, Premila Paul
1. Medical Officer, Department of Pediatrics, Vardhman Mahavir Medical College and Safdarjung Hospital, Krishna Nagar, New Delhi, India.
2. Assistant Professor, Department of Pediatrics, Albert Einstein College of Medicine, Attending Physician, Division of Pediatric Gastroenterology and Nutrition,
Children’s Hospital at Montefiore, 3415 Bainbridge Avenue, Bronx, NY 10467-2490.
3. Graduate Student, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
4. Ex Professor, Department of Pediatrics, Vardhman Mahavir Medical College, Safdarjung Hospital, New Delhi, India.
Correspondence
Dr. Rohit Kapoor,
86-A GTB Enclave Opp. GTB Hospital F- Pocket New Delhi-10093, India.
E-mail: rohitvmmc@gmail.com
Langerhans cell histiocytosis (LCH) is a disorder associated with proliferation of Langerhans cells in various organs. LCH secondary to multisystem involvement can present in a variety of ways. Because of its infiltrative nature, LCH can involve the skin, lymph nodes, the lung or the liver. Jaundice in LCH is a manifestation of liver disease; biliary dilatation secondary to lithiasis or may be due to coexistent Niemann-Pick disease. However, a case of cholestasis has been very rarely described. Cholestasis may result from lymph nodes obstructing the porta hepatis. In this report, we describe a case of type II histiocytosis X with obstructive cholestasis and pulmonary involvement in the form of cysts without significant lymphadenopathy at the porta.
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